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Price: $75.00

Biotics Research EFA-Sirt Supreme supplies a unique, highly concentrated essential fatty acid blend, providing a extremely effective relative combination of EPA, DHA and GLA, with all natural mixed tocopherols, specially formulated to be high in y(gamma)-Tocopherol.

Why do patients need EFA-Sirt Supreme?
The unique composition of EFA-Sirt Supreme provides a balance of key nutrients that current research has shown to support healthy cardiovascular function.  A large amount of supportive scientific research shows that the consumption of Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) Omega-3 fatty acids may reduce the risk of coronary heart disease.

Omega-3 fatty acids (FA) have been shown to affect platelet aggregation, blood viscosity, plasma levels of fibrinogen, PF4 and
beta-thromboglobulin and capillary flow. These effects are believed to be functions of membrane fluidity. Omega-3 fatty acids support healthy blood lipid profiles, normal healthy blood pressure, stimulate Nitric Oxide (NO) and support healthy, normal blood sugar and insulin levels. Omega-3 fatty acids help to suppress ACE, TGA beta, SREBP and function as PPAR agonists.  Additionally, Omega-3 fatty acid supplementation increases FA oxidation, which research suggests helps to decrease adipose tissue and serves to improve endothelial function.

EPA-derived eicosanoids reduce the production of proinflammatory eicosanoids such as LT-B4, PAF, and cytokines such a TNF-a and IL-1.  Evidence suggests that EPA must be incorporated into cell membrane phospholipids for its beneficial affects on eicosanoid metabolism to be realized.

DHA is not only essential for neural function, it is also an important component of cell membranes and supports normal healthy blood pressure.  DHA generally appears to improve cell membrane function via improved receptor function and signal transduction. DHA is converted by several mechanisms into docosatrienes and resolvins, which have anti-inflammatory properties. The activity may very well be due to the fatty acids effects modifying genetic expression, according to recent research.

Gamma linolenic acid (GLA), the good Omega-6 fatty acid, is elongated to DGLA, the biologically active form from which eicosanoids are derived. DGLA metabolites reduce the formation of the arachidonate-derived prostaglandins, leukotrienes, platelet-activating factors and supports normal healthy blood pressure. DGLA reduces aldosterone, sympathetic tone and RAAS activity. Low levels of DGLA are associated with increased cardiac risk.

Gamma Tocopherol (g-Tocopherol) Humans derive significant benefit from g-Tocopherol, a key component of the mixed tocopherols supplied by a healthy diet high in vegetable consumption. g-Tocopherol has naturietic activity, supports normal healthy glucose and insulin levels, and improves antioxidant defenses, serving as a component in minimizing cellular damage resulting from the production of radical oxygen species. Unlike a-Tocopherol, g-Tocopherol and its primary metabolite g-CECH, have been shown to inhibit the synthesis of PGE2.

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